The SafeDESIgn imaging-based toxicity reporter platform for chemical safety assessment

Tuesday 28 January 2020

10.00-10.45 am EST, 16-16.45 CET - (7 am California, 10 am New York, 15.00 London, 16.00 Zurich, 20.30 New Delhi, 24.00 Tokyo)

Signup here

This virtual meeting will include a perspective and a discussion session. 

High drug attrition rates are the main cause for the (exponentially) increasing healthcare cost. The lack of predictive in vitro models to either accurately test drug efficacy or determine toxic side effects in an early phase of drug development is causing this high failure rate. At Leiden University we developed the innovative SafeDESIgn reporter platform that we use to accurately assess the efficacy and/or safety of chemicals. The generated fluorophore reporter cell lines can be imaged with a confocal microscope over time so that we can accurately quantify the early dynamic adaptive signaling changes. By doing so we can not only determine if a chemical at a certain concentration is toxic, but also which adaptive/adverse pathways are activated. This is crucial information if we want to predict human safety levels for these chemicals.

Over the last couple of years we further developed the system improving the throughput and robustness. Besides the standard 2D culturing method, the reporters can also be cultured in 3D allowing for repeated dosing in a more differentiated liver spheroid system. Currently we are commercializing the technology in a Leiden University CRO based spin-off called “DESI” (Drug efficacy & Safety Imaging). In the webinar we will further explain the reporter platform, show some neat fluorophore time-lapse movies, give some examples of how we applied the technology in some industrial case studies and there will be plenty of time for discussion and Q&A.

Latest Tweets

Edelweiss Connect (Yesterday)
Join us for the upcoming #SaferWorldbyDesign webinar Validated HepaRG™ mechanistic methods as a tool for dynamic a… https://t.co/jQJSMIwWB3
Edelweiss Connect (4 weeks ago)
RT @barryhardy: Communicating cell culturing protocol knowledge - initial #HepaRG examples available on #saferworldbydesign https://t.co/O…
Edelweiss Connect (4 weeks ago)
RT @oak2: You may wonder: what does it mean, going digital, for a cell product like #HepaRG. This encompasses a set of various services suc…
Edelweiss Connect (2 months ago)
RT @skillsmatter: Next week at the #fsharpX 2020 virtual conference: See how #TypeProviders are built. @Odytrice will be sharing an exam…
Edelweiss Connect (2 months ago)
RT @Scivera: Did you miss our SaferWorldbyDesign webinar with @EdelweissConn - "Exploring and selecting safer chemical alternatives through…

Get in touch

  • Address: Edelweiss Connect GmbH
    Technology Park Basel
    Hochbergerstrasse 60C
    CH-4057 Basel / Basel-Stadt
    Switzerland

USA office

  • Address: Edelweiss Connect Inc
    Research Triangle Park NC
    800 Park Offices Dr
    Durham, NC 27709
    USA