SaferWorldbyDesign Webinar: Use of alternative skin models for animal-free safety and efficacy testing in dermatology research

Tuesday 11 August 2020

16-16:45 CEST - (7 am California, 10 am New York, 3 pm London, 4 pm Zurich, 7:30 pm New Delhi, 11 pm Tokyo)

This virtual meeting will include a perspective by Hanan Osman-Ponchet (Founder & President, PKDERM) followed by a discussion session.

A set of alternative in vitro and ex vivo skin models can be used to evaluate the safety and efficacy of topical products. For example, 2D-cell culture derived from human skin can be used to evaluate anti-inflammatory, anti-aging, skin pigmentation, wound healing, or to predict skin sensitization of active molecules. On the other hand, 3D-human reconstructed skin models can be used to evaluate skin irritation (safety), skin sensitization (safety), or even anti-inflammatory properties (efficacy) of topical products. Excised human skin model, on the other hand, is used as the gold standard to evaluate dermal absorption, skin metabolism, and drug transporters, since dermal absorption data are of importance in toxicological risk assessment.

But what is the most appropriate skin model to be used for specific assessment of safety and efficacy in dermatology based on the development stage?

In this webinar, an overview of the in vitro alternative skin models will be presented with practical examples on the advantages and limitations of each model in safety and efficacy assessment, with a focus on dermal absorption and inflammation testing.

Latest Tweets

Edelweiss Connect (5 weeks ago)
Read our latest #SaferWorldbydesign newsletter highlighting SaferSkin™ new features and products. #SaferSkin… https://t.co/z9SmrlJ3Yb
Edelweiss Connect (5 weeks ago)
Curation of drug-induced mechanistic toxicological processes and adverse outcome pathway in (DILI) Presented by Cu… https://t.co/8n0QoR3gXa
Edelweiss Connect (5 weeks ago)
The approach may be further extended by additional in silico and in vitro methods to strengthen the weight of evide… https://t.co/oLCdYGMTnW
Edelweiss Connect (5 weeks ago)
Our #SaferSkin™ app implements three well-adopted approaches to perform an integrated analysis of the OECD-approved… https://t.co/MA7DY0RdwO
Edelweiss Connect (6 weeks ago)
#SaferWorldbyDesign & @MultiCASEInc present: Use of in silico methods for assessing toxicity #QSAR #insilico… https://t.co/AgoolrhT7M

Get in touch

  • Address: Edelweiss Connect GmbH
    Technology Park Basel
    Hochbergerstrasse 60C
    CH-4057 Basel / Basel-Stadt
    Switzerland

USA office

  • Address: Edelweiss Connect Inc
    Research Triangle Park NC
    800 Park Offices Dr
    Durham, NC 27709
    USA