Hands-on Training: in vitro flow system and FAIR data integration
for safety assessment

Joint workshop and hands-on training on advanced cell culture flow system
and implementation of FAIR data principles for safety assessment.



This event is postponed. The new date will be announced on this page.







Edelweiss Connect Laboratory

Technology Park Basel
Hochbergerstrasse 60C Basel




The training is organised at Edelweiss Connect facilities in Basel, Switzerland in collaboration with the Swiss Centre for Applied Human Toxicology (SCAHT) and
Kirkstall Ltd.

The event is dedicated to scientists from the chemical and pharmaceutical industry, academics, consultants and CROs interested in the application of advanced cell culture systems, to gain experience with state-of-the-art experimental data management and integrated in vitro - in silico approaches, including an overview on regulatory guidance on the use of alternative methods for safety assessment of chemicals and drug development.

The training includes both theory and practices of advanced cell culture techniques and data management practices through a combination of lectures, demonstrations and practical hands-on experience. The event combines hands-on training with seminar sessions,


Early bird fees available until 31 December 2018

to ensure participants have all the necessary skills and knowledge to commence work using the cell flow conditions for either industrial or academic applications.

A hands-on lab training will be given using the Quasi Vivo® system, an advanced interconnected cell culture flow system, engineered to provide in vivo like conditions for cell growth.

The latest data management approaches, applied within EU-ToxRisk and OpenRiskNet projects towards making in vitro experimental data findable, accessible, interoperable and reusable (FAIR data principles), will be presented and demonstrated during the training. Ongoing discussions on FAIR are mainly related to large projects and public databases, but we will show that following these concepts is also very beneficial when used inside a single institution to improve the sustainability of data and the reproducibility of research.

Get familiar with organ-on-a-chip technology and learn how in vitro & in silico data integration can enhance your research and apply to safety assessment!

In collaboration with the Swiss Centre for Applied Human Toxicology


Day 1

Introduction lectures on risk assessment, 3Rs, overview of in vitro systems, lab demonstrations on Quasi-Vivo® system and data management workflows

09:00   Welcome and introduction to workshop activities  
09:15   Lectures:
  1. Regulatory considerations (Dr. Rex FitzGerald, SCAHT)
  2. Early drug development (speaker to be confirmed)


Download pdf leaflet Download pdf Program

10:45   Coffee Break  
11:00   Lectures:
  1. Introduction to flow systems using Quasi-Vivo® (by Kirkstall)
  2. Best practices in data management and application of FAIR data principles (Dr. Thomas Exner, Edelweiss Connect)
12:00   Lunch (not included)
  1. Choosing and Calibrating a Pump for Quasi-Vivo® system (by Kirkstall)
13:30   Parallel demonstration (session I)
GROUP 1 - Lab demo:
  • Assembling Quasi-Vivo® system
  • Priming Quasi-Vivo®
  • Calibration of Pump
  • Transfer of cells and start flow experiment
GROUP 2 - Lab demo:
  • Data management and data integration workflows
  • Data and metadata schemas creation and use
  • Preparation and uploading of data using Edelweiss DataExplorer application
15:00   Coffee break
15:30   Parallel demonstration (session I)
Group 1 - Data demo / Group 2 - Lab demo
17:00   End of training day 1  


Day 2

Hands-on training on Quasi-Vivo® system, applications and discussion on the results

09:00   Lectures:
  1. OpenRiskNet, an open e-infrastructure to support data sharing, knowledge integration and in silico analysis and modelling in risk assessment (Dr. Thomas Exner, Edelweiss Connect)
09:30   Parallel demonstration (session III)
GROUP 1 - Lab demo:
  • Check experiment and reverse flow
  • Remove cells, cell viability assay, empty and wash chambers
GROUP 2 - Lab demo:
  • Use of the data API and Jupyter notebooks in modelling applications (demonstration on OpenRiskNet case studies)
11:00   Coffee break
11:30   Lectures:
  1. Applications of Quasi-Vivo® (by Kirkstall)
12:00   Lunch (not included)
13:00   Parallel demonstration (session IV)
Group 1 - Data demo / Group 2 - Lab demo
14.30   Discussion of results, training outcomes and feedback:
  • Use of Quasi-Vivo® flow system, design of 3D and co-culture experiments
  • Data management and integration testing approaches
15.30   End of training day 2    

Get in touch

  • Address: Edelweiss Connect GmbH
    Technology Park Basel
    Hochbergerstrasse 60C
    CH-4057 Basel / Basel-Stadt

USA office

  • Address: Edelweiss Connect Inc
    Research Triangle Park NC
    800 Park Offices Dr
    Durham, NC 27709